Searchable abstracts of presentations at key conferences in endocrinology

ea0056ep144 | Reproductive Endocrinology | ECE2018

Endocrine disruption and oxidative stress implications of imipenem therapy in the ovary of ‘wistar’ rats

Tahri Amal , Naifar Manel , Daoud Salima , Kacem Faten Haj , Rebai Tarek , Ayedi Fatma , Abid Mohamed , Sahnoun Zouheir

Imipenem (IMP) is a carbapenem antibiotic mainly used to treat nosocomial infection diseases. We aimed to evaluate the oxidative stress of therapeutic doses of imipenem (IMP) on the ovary of ‘wistar’ rats. In this respect, female rats were divided into four groups: animals were intraperitoneally treated with physiological serum, 30, 50 and 80 mg/kg of IMP for one week. We found that therapeutic doses of this drug did not significantly affect the levels of ovarian mal...